ChE 510 Molecular Thermodynamics in Polymers and Biological Systems (3+0+0) 3 ECTS 8
(Polimerler ve Biyolojik Sistemlerde Moleküler Termodinamik)
Principles of statistical thermodynamics. The stable states of macromolecules. Molecular interactions. Diffusion, reaction kinetics and electrostatic properties related to biomolecular and polymeric systems. Cooperativity and binding. Applications of principles of statistical thermodynamics to biological systems and polymers using simple models.

ChE 511 Polymer Processing Principles and Modeling (3+0+0) 3 ECTS 8
(Polimer İşleme İlkeleri ve Modelleme)
Categories of polymeric materials. Morphology and structuring of polymers; surface properties. Analysis of polymer processing operations such as injection moulding, extrusion, calendaring, coating, fiber spinning, tubular film blowing and mixing. Computer modeling and design of polymer processing machinery.
Prerequisite: Consent of the instructor.

ChE 512 Multi-Scale Modeling of Macromolecular Systems (3+0+0) 3 ECTS 8
(Makromoleküler Sistemlerin Değişik Ölçeklerde Modellenmesi)
Atomistic and nano-scale modeling of complex polymer systems. Techniques for bridging the gap between atomistic and coarse-grained simulations. Applications of these techniques to multicomponent, polymeric and biological systems.

ChE 516 Computational Biology and Bioinformatics (3+0+0) 3 ECTS 8
(Hesapsal Biyoloji ve Biyoinformatik)
Modeling and simulations of biomolecular systems. Sequence-structure-dynamics and function paradigm in proteins. Bioinformatic approaches in sequence analysis and structure prediction. Computer modeling and engineering of protein-protein, protein-DNA and protein- drug binding interactions. Molecular aspects of biochemical and biophysical networks. The relationship between microscopic and macroscopic properties of biological systems.

ChE 518 Conformational Statistics and Dynamics of Polymers (3+0+0) 3 ECTS 8
(Polimerlerin Konformasyon İstatistiği ve Dinamiği)
Structural and configurational properties of polymer chains. Random walk approach, freely jointed chain models. Rotational Isomeric State formalism. Stochastics of rotational motions, Monte Carlo and Molecular Dynamics simulations of real polymeric systems in solution and in the bulk state.

ChE 520 Upstream and Downstream Processes for Industrial Bio/Products (3+0+0) 3 ECTS 8
(Endüstriyel Biyoürünlerin üretimine yönelik süreçler ve üretim sonrası ayırma işlemleri)
Upstream processes, Strain Engineering, Prediction of optimum yields and pathways, Design principles of Metabolic Networks, Separation and Purification of biochemicals, Isolation of products, Purification, Scale-up of selected operations.

ChE 529 Metabolic Engineering (3+0+0) 3 ECTS 8
(Metabolik Mühendisliği)
Aims of metabolic engineering and examples of applications.Cellular metabolism and construction of metabolic networks. Transcriptional regulation and signal transduction. Properties of stoichiometric matrix and the solution space. Flux balance analysis. Metabolic control analysis.

ChE 540 Thermochemical Kinetics (3+0+0) 3 ECTS 8
(Termokimyasal Kinetik)
Elementary steps and mechanisms of reactions. Theory of reaction rates, collision theory, potential energy surfaces, transition state theory, unimolecular and bimolecular reactions. Estimation of thermochemical and kinetic parameters using empirical techniques and quantum mechanical calculations.

ChE 541 Microreaction Engineering (3+0+0) 3 ECTS 8
(Mikrotepkime Mühendisliği)
Fundamental principles associated with different types of catalytic microreactors. Modeling, simulation and operation of microreactors. Microreactor design and construction techniques. Selected applications of microreactors in industrial processes.

ChE 542 Analysis of Sustainable Technologies (3+0+0) 3 ECTS 8
(Sürdürülebilir Teknolojilerin Çözümlemesi)
Analysis of natural sustainable energy resources: agricultural, biomass, solar, wind, geothermal and other resources. Existing and near-future sustainable energy technologies. Economical analysis of sustainable technologies. Legal, social and environmental aspects. Basic design of sustainable energy conversion processes.

ChE 543 Catalysis for Green Technologies (3+0+0) 3 ECTS 8
(Yeşil Teknolojiler için Kataliz)
Environmentally benign catalytic production technologies for energy and materials. Catalysis for mobile and stationary power generation. Adsorbents for hydrogen storage. Catalysts and adsorbents for reduction and prevention of greenhouse gas emissions: methane conversion, carbon dioxide utilization and sequestration.

ChE 545 Advances in Catalytic Production Processes of Synthetic Fuels (3+0+0) 3 ECTS 8
(Sentetik Yakıtların Katalitik Üretim Süreçlerinde İlerlemeler)
Novel catalytic routes and reactor configurations for conversion of synthesis gas to liquid fuels such as diesel, methanol or ammonia. Fundamentals, operation and design of microstructured and cascade reactors. Techniques for coating catalysts on microchannels. Use of catalytic microstuctured reactors in petrochemical industries.

ChE 550 Statistical Methods in Chemical Processes (3+0+0) 3 ECTS 8
(Kimyasal Süreçlerde İstatistiksel Yöntemler)
Review of statistical principles as applied to chemical engineering problems. Linear and non-linear regression analysis. Factorial and optimal designs of experiments. Multivariate statistical process analysis. Time series analysis and forecasting methods.

ChE 551 Linear Statistical Models in Chemical Engineering (3+0+0) 3 ECTS 10
( Kimya Mühendisliğinde Doğrusal İstatistiksel Modeller)
Introduction to frequency interpretation of probability, the law of large numbers and Monte Carlo simulations. Linear regression, model adequacy checking, transformations and weighted least squares. One and two-way ANOVA. Categorical predictions in regression. Multicollinearity in regression: Subset selection methods, Cross-validation and Bootstrap sampling. Ridge and Lasso regression. Robust regression.

ChE 555 Applied Mathematics and Modeling for Chemical Engineers I (2+0+2) 3 ECTS 8
(Kimya Mühendisleri için Uygulamalı Matematik ve Modelleme I)
Modeling and mathematical formulation of lumped-parameter and distributed-parameter systems encountered in chemical engineering. Review of analytical and numerical methods used in the solution of ordinary and partial differential equations.

ChE 556 Applied Mathematics and Modeling for Chemical Engineers II
(Kimya Mühendisleri için Uygulamalı Matematik ve Modelleme II) (3+0+0) 3 ECTS 8
Modeling of stagewise processes and the solutions of resulting difference and difference differential equations by operator and Z-transform methods. Applications of the theory of matrices to chemical engineering processes. Operator theoretic methods and their use in solving problems of transport phenomena and chemically reacting systems.

ChE 566 Process Engineering Strategy (3+0+0) 3 ECTS 8
(Süreç Mühendisliği Stratejisi)
Introduction to process analysis and conceptual process design via a study of the creation and assessment of processing alternatives, optimization of recycle systems and engineering in the presence of uncertainty.

ChE 576 Chemical Process Control Strategies (3+0+0) 3 ECTS 8
(Kimyasal Süreç Denetimi Stratejileri)
Feed-forward control, ratio control, cascade control, selective control, internal model control and multivariable control techniques. Computer control of chemical processes.

ChE 577 Design and Operation under Uncertainty and Risk (3+0+0) 3 ECTS 8
(Belirsizlik ve Risk Altında Tasarım ve İşletim)
Review of probability, statistics, and optimization. Feasibility, flexibility, and operability. Flexibility targeting and flexibility indexing. Design and operation under uncertainty and risk. Flexible design and feasible operation. Flexibility maximization and risk minimization for static and dynamic systems via optimization models. Monte Carlo simulation for design under uncertainty. Flexibility and risk assessment and targeting in design and operation.

ChE 578 Dynamic Optimization of Chemical Processes (3+0+0) 3 ECTS 8
(Kimyasal Süreçlerin Dinamik Eniyilemesi)
Optimization of chemical processes under unsteady-state operation. Application of the optimal control theory and numerical algorithms to lumped-parameter and distributed-parameter chemical engineering systems. Iterative and simultaneous solution of differential/algebraic optimization problems. Nonlinear-model-based predictive control of chemical engineering systems.
Prerequisite: Consent of the instructor.

ChE 579 Graduate Seminar (0+1+0) 0 Pass/Fail ECTS 2
(Lisansüstü Seminer)
Seminars offered by faculty, guest speakers and/or graduate students designed to widen students' perspectives on specific topics of interest and to expand their range of scientific research techniques and publication ethics.

ChE 580-599 Special Topics in Chemical Technology (3+0+0) 3 ECTS 8
(Kimyasal Teknolojide Özel Konular I, II)
Special topics of current interest in chemical engineering technology selected to suit the interests of students and faculty.

ChE 610 Advanced Topics in Polymer Science and Engineering (3+0+0) 3 ECTS 10
(Polimer Bilimi ve Mühendisliğinde İleri Konular)
Recent advances in theoretical and experimental approaches for the investigation of polymeric systems. Statistical mechanics of homogeneous and heterogeneous systems. Advanced methods for the characterization of molecular structure and properties. Segmental orientation in polymer networks and liquid crystalline materials. Techniques and approaches for high technology materials design.

ChE 611 Structural Properties of Disordered Materials (3+0+0) 3 ECTS 10
( Amorf Malzemelerin Yapısal Özellikleri)
Structure and Topology of Disordered materials with emphasis on glasses and polymers. Structure determination at short- and intermediate-range scales using advanced characterization techniques. Three-dimensional structural models of disordered systems.

ChE 620 Current Topics in Biological Systems Engineering (3+0+0) 3 ECTS 10
(Biyolojik Sistemler Mühendisliğinde Güncel Konular)
Literature survey on selected topic(s) in biological systems engineering. Rational design approaches in biotechnological processes. Developments in biotechnology in post-genomic era. Recent computational methods in systems biology and their applications. Discussion of future research directions.

ChE 621 Phase Equilibria (3+0+0) 3 ECTS 10
(Evre Dengeleri)
An advanced study of fundamental concepts in classical and molecular thermodynamics. Solution thermodynamics, vapor-liquid and liquid-liquid equilibria, and chemical reaction equilibria in multicomponent systems; estimation of related thermodynamic properties.

ChE 622 Statistical Thermodynamics (3+0+0) 3 ECTS 10
(İstatistiksel Termodinamik)
Review of classical thermodynamics and quantum mechanics. Ensembles and partition functions. Estimation of thermodynamic properties. Fluctuations. Boltzmann, Fermi-Dirac and Bose-Einstein statistics. Ideal gases. Crystals. Imperfect gases. Introduction to lattice statistics and to liquids.

ChE 626 Advanced Computations in Phase Equilibria (3+0+0) 3 ECTS 10
(İleri Evre Dengeleri Hesaplamaları)
An advanced computational study of multicomponent vapor-liquid and liquid-liquid equilibrium systems. Computer calculations of nonidealities in gas and liquid phases using theories of molecular thermodynamics.

ChE 631 Advanced Fluid Mechanics (3+0+0) 3 ECTS 10
(İleri Akışkanlar Mekaniği)
Tensor algebra; continuum hypothesis; continuity and momentum equations; Lagrangian and Eulerian approach; ideal and potential flows; Navier - Stokes equation; exact and approximate solutions; creeping flow; laminar and turbulent boundary layer theory; lubrication theory.

ChE 634 Interfacial Transport Phenomena (3+0+0) 3 ECTS 10
(Arayüzeysel Taşınım Olayları)
Modeling linear and nonlinear liquids with a deflecting interface. Jump conditions; physical properties at the interface. Formulation of interfacial conditions. Solution to mass, momentum, and constitutive equations. Perturbation methods and linear stability analysis; applications to various problems including Rayleigh jet, Rayleigh-Taylor instability, and other problems.

ChE 637 Advanced Mass Transfer (3+0+0) 3 ECTS 10
(İleri Kütle Aktarımı)
Mechanisms of mass transfer. Equations of change for multicomponent systems. Mass transfer in laminar and turbulent regimes. Concentration distributions with more than one independent variable. Mass transfer with chemical reactions. Interfacial mass transfer. Interphase transport in nonisothermal systems.

ChE 642 Catalytic Reactor Analysis and Design (3+0+0) 3 ECTS 10
(Katalitik Reaktör Analizi ve Tasarımı)
Fundamentals of heterogeneous catalytic reaction systems with emphasis on the interaction of chemical and physical rate processes. Microkinetic analysis of solid-catalyzed reactions with and without external and/or internal heat and mass transfer resistances at the particle level. Macrokinetic analysis of two-phase catalytic reactors including design and simulation of fixed-bed reactors by pseudohomogeneous and heterogeneous models; scale up strategies. Introduction to two-phase catalytic micro-structured reactors and design by numbering up.

ChE 670 Advanced Topics in Chemical Process Control (3+0+0) 3 ECTS 10
(İleri Kimyasal Proses Kontrol Konuları)
Review of time series analyses; applied stochastic control theory including minimum variance control, LQG control, self-tuning control and adaptive control. Generalized predictive control. Current topics in chemical process control.

ChE 672 Advanced Process Control (3+0+0) 3 ECTS 10
(İleri Süreç Denetimi)
Review of conventional control. State space basics observability, controlability, state variable feedback, Luenberger observer, Lyapunov stability. Multivariable process control. Interaction concept, multivariable controller design, decoupling control. Digital process control. z-transform, difference equations, discrete control algorithms.

ChE 680-689, 691-698 Special Studies in Advanced Chemical Engineering (3+0+0) 3 ECTS 10
(İleri Kimya Mühendisliğinde Özel Konular)
Advanced topics of current interest selected to suit the interests of students and faculty.

ChE 690 M.S.Thesis ECTS 60
(Yüksek Lisans Tezi)

ChE 699 Guided Research (2+0+4) 4 ECTS 10
(Yönlendirilmiş Araştırmalar)
Research in the field of Chemical Engineering, by arrangement with members of the faculty; guidance of doctoral students towards the preparation and presentation of a research proposal.

ChE 69 A Guided Research in Ph.D. II (0+4+0) 0 Pass/Fail ECTS 10
(Doktorada Yönlendirilmiş Çalışmalar II)
Continued research in chemical engineering. Supervision of doctoral research proposals and presentations.

ChE 69 B Guided Research in Ph.D. III (0+4+0) 0 Pass/Fail ECTS 10
(Doktorada Yönlendirilmiş Çalışmalar III )
Continued research in chemical engineering. Supervision of doctoral research proposals and presentations.

ChE 69 C Guided Research in Ph.D. IV (0+4+0) 0 Pass/Fail ECTS 10
(Doktorada Yönlendirilmiş Çalışmalar IV )
Continued research in chemical engineering. Supervision of doctoral research proposals and presentations.

ChE 69 D Guided Research in Ph.D. V (0+4+0) 0 Pass/Fail ECTS 10
(Doktorada Yönlendirilmiş Çalışmalar V )
Continued research in chemical engineering. Supervision of doctoral research proposals and presentations.

ChE 700 Graduate Seminar (0+1+0) 0 ECS 2
(Lisansüstü Seminer)
Seminars offered by faculty, guest speakers and graduate students designed to widen students' perspectives on specific topics of interest and to expand their range of scientific research techniques and publication ethics.

ChE 790 Ph.D. Thesis ECTS 120
(Doktora Tezi)